类风湿关节炎中的淋巴增殖性恶性肿瘤：20例病例研究。
Lymphoproliferative malignancy in rheumatoid arthritis: a study of 20 cases.
作者信息
Symmons D P, Ahern M, Bacon P A, Hawkins C F, Amlot P L, Jones E L, Prior P, Scott D L
出版信息
Ann Rheum Dis. 1984 Apr;43(2):132-5. doi: 10.1136/ard.43.2.132.
Abstract
A series of 20 patients with definite or classical rheumatoid arthritis who subsequently developed a lymphoproliferative malignancy are described. The mean time between the onset of the 2 diseases was 13.2 years. A wide range of types of non-Hodgkin's lymphoma and Hodgkin's disease were found; there were no unusual histological features in the lymphomas. Although many of the patients had had gold, penicillamine, and other second-line drugs, none of them had received cytotoxic drugs, and there was no evidence that therapy was a cause of their malignancies. The likely cause of the association is a predisposition to both diseases.
摘要
本文描述了20例确诊为典型类风湿性关节炎且随后发生淋巴增殖性恶性肿瘤的患者。两种疾病发病的平均间隔时间为13.2年。发现了多种类型的非霍奇金淋巴瘤和霍奇金病；淋巴瘤中没有异常的组织学特征。尽管许多患者曾使用金制剂、青霉胺和其他二线药物，但他们均未接受过细胞毒性药物治疗，也没有证据表明治疗是其恶性肿瘤的病因。这种关联的可能原因是对这两种疾病都有易感性。
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