具有潜在胃泌素分泌抑制和抗溃疡活性的化合物。IV. 3-和4-苯基-2-氧代-5-[2-(甲基哌嗪-1-基)乙酰基]-1H-2,3,4,5-四氢吡啶并[2,3-b][1,4]二氮杂卓的合成
[Compounds with potential gastric antisecretory and anti-ulcer activity. IV. Synthesis of 3- and 4-phenyl-2-oxo-5-[2-(methylpiperazine-1-yl)-acetyl]- 1H-2,3,4,5-tetrahydropyrido[2,3-b] [1,4]diazepine].
作者信息
Bianchi M, Butti A
出版信息
Farmaco Sci. 1984 Feb;39(2):162-70.
PMID:6714411
Abstract
Pyrenzepinelike compounds, namely 2-oxo-3-phenyl- and 2-oxo-4-phenyl-5-[2-(4-methylpiperazin-1-yl)-acetyl]- 1H-2,3,4,5-tetrahydropyrido[2,3-b] [1,4]diazepine [(VIII) and (XIV) resp.] were synthetized. Both compounds were found to be inactive in rats against carbachol stimulated gastric secretion and cold + restraint induced ulcers.
摘要
合成了吡仑西平样化合物，即2-氧代-3-苯基-和2-氧代-4-苯基-5-[2-(4-甲基哌嗪-1-基)-乙酰基]-1H-2,3,4,5-四氢吡啶并[2,3-b][1,4]二氮杂卓[分别为(VIII)和(XIV)]。发现这两种化合物对大鼠对抗卡巴胆碱刺激的胃液分泌和寒冷+束缚诱导的溃疡均无活性。
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