Perrin D G, Cutz E, Becker L E, Bryan A C
Pediatrics. 1984 May;73(5):646-51.
Recent studies have implicated an abnormality in carotid body structure and function in the pathogenesis of sudden infant death syndrome (SIDS). In the present investigation, the light and electron microscopic findings in carotid bodies from ten victims of SIDS were compared with those in six control infants and five infants dying of congenital heart disease. The cross-sectional area of carotid body chemoreceptor cells and the frequency, distribution, and size of neurosecretory granules were assessed morphometrically. The area of carotid body occupied by chemoreceptor cells (the functional area) was comparable in SIDS victims, control infants, and infants with congenital heart disease. By electron microscopy, the carotid body chief cells from all groups contained numerous electron-dense neurosecretory granules. Distribution, frequency, and size of neurosecretory granules in SIDS victims and control infants did not differ significantly. Morphology of carotid bodies from SIDS victims was found to be normal. The presence of neurosecretory granules in chemoreceptor cells of SIDS victims suggests that the cellular mechanism of neurotransmitter synthesis and storage is not altered.
最近的研究表明，颈动脉体结构和功能异常与婴儿猝死综合征（SIDS）的发病机制有关。在本研究中，将10例SIDS受害者的颈动脉体的光镜和电镜检查结果与6例对照婴儿及5例死于先天性心脏病的婴儿的结果进行了比较。采用形态计量学方法评估了颈动脉体化学感受细胞的横截面积以及神经分泌颗粒的频率、分布和大小。SIDS受害者、对照婴儿和先天性心脏病婴儿中，化学感受细胞所占的颈动脉体面积（功能区）相当。通过电子显微镜观察，所有组的颈动脉体主细胞均含有大量电子致密的神经分泌颗粒。SIDS受害者和对照婴儿的神经分泌颗粒的分布、频率和大小无显著差异。发现SIDS受害者的颈动脉体形态正常。SIDS受害者化学感受细胞中存在神经分泌颗粒，这表明神经递质合成和储存的细胞机制未发生改变。
