Sch 29482对清除鼻咽部脑膜炎奈瑟菌携带者体内该菌的效果评估。
Evaluation of Sch 29,482 in the eradication of Neisseria meningitidis from nasopharyngeal carriers.
作者信息
Pugsley M P, Dworzack D L, Sanders C C, Sanders W E
出版信息
Antimicrob Agents Chemother. 1984 Apr;25(4):494-6. doi: 10.1128/AAC.25.4.494.
Abstract
Fifty-eight chronic carriers of Neisseria meningitidis were given 250 mg of Sch 29,482 or placebo orally every 6 h for 4 days. Although 22 of 29 subjects taking Sch 29,482 became culture negative while taking the drug, only five were culture negative 2 weeks posttherapy. There were no significant adverse reactions.
摘要
58名脑膜炎奈瑟菌慢性携带者每6小时口服250毫克Sch 29,482或安慰剂，共服用4天。虽然服用Sch 29,482的29名受试者中有22人在服药期间培养结果转为阴性，但治疗后2周只有5人培养结果为阴性。未出现明显不良反应。
相似文献
1
Evaluation of Sch 29,482 in the eradication of Neisseria meningitidis from nasopharyngeal carriers.Sch 29482对清除鼻咽部脑膜炎奈瑟菌携带者体内该菌的效果评估。
Antimicrob Agents Chemother. 1984 Apr;25(4):494-6. doi: 10.1128/AAC.25.4.494.
2
Evaluation of single-dose ciprofloxacin in the eradication of Neisseria meningitidis from nasopharyngeal carriers.单剂量环丙沙星清除鼻咽部携带者脑膜炎奈瑟菌的评估。
Antimicrob Agents Chemother. 1988 Nov;32(11):1740-1. doi: 10.1128/AAC.32.11.1740.
3
Evaluation of the effect of Rifampin on the nasopharyngeal carriage of Neisseria meningitidis. A preliminary report.利福平对脑膜炎奈瑟菌鼻咽部携带影响的评估。初步报告。
Int Z Klin Pharmakol Ther Toxikol. 1971 Apr;4(3):316-20.
4
Azithromycin compared with rifampin for eradication of nasopharyngeal colonization by Neisseria meningitidis.阿奇霉素与利福平用于根除脑膜炎奈瑟菌鼻咽部定植的比较
Pediatr Infect Dis J. 1998 Sep;17(9):816-9. doi: 10.1097/00006454-199809000-00013.
5
Nasopharyngeal carriers among contact of patients of Neisseria meningitidis infection in Delhi.
Indian J Med Res. 1987 Oct;86:429-32.
6
[Meningococcal meningitis in Spain (1978-1981). III. Susceptibility of the meningococcal strains isolated from patients and carriers to the main agents used in the treatment and chemoprophylaxis of meningococcal infections].[西班牙的脑膜炎球菌性脑膜炎（1978 - 1981年）。III. 从患者和带菌者分离出的脑膜炎球菌菌株对用于治疗和化学预防脑膜炎球菌感染的主要药物的敏感性]
Rev Sanid Hig Publica (Madr). 1983 May-Jun;57(5-6):587-602.
7
Persistence of Neisseria meningitidis in the upper respiratory tract after intravenous antibiotic therapy for systemic meningococcal disease.全身性脑膜炎球菌病静脉注射抗生素治疗后，脑膜炎奈瑟菌在上呼吸道的持续存在。
J Infect Dis. 1985 Feb;151(2):370-1. doi: 10.1093/infdis/151.2.370.
8
Nasopharyngeal carriage of Neisseria meningitidis in general population and meningococcal disease.普通人群中脑膜炎奈瑟菌的鼻咽部携带情况与脑膜炎球菌病
J Commun Dis. 1990 Dec;22(4):264-8.
9
10
[Efficacy of rifampicin in the treatment of Meningococcus carriers].
Rev Chil Pediatr. 1981 Mar-Apr;52(2):146-8.
引用本文的文献
1
Antibiotics for preventing meningococcal infections.用于预防脑膜炎球菌感染的抗生素。
Cochrane Database Syst Rev. 2013 Oct 25;2013(10):CD004785. doi: 10.1002/14651858.CD004785.pub5.
2
Prophylactic use of antibiotics for prevention of meningococcal infections: systematic review and meta-analysis of randomised trials.预防性使用抗生素预防脑膜炎球菌感染：随机试验的系统评价和荟萃分析
Eur J Clin Microbiol Infect Dis. 2005 Mar;24(3):172-81. doi: 10.1007/s10096-005-1297-7.
本文引用的文献
1
Oral absorption and tolerance in man, of a new penem antibiotic, Sch 29428.新型青霉烯类抗生素Sch 29428在人体中的口服吸收及耐受性
J Antimicrob Chemother. 1982 Feb;9 Suppl C:239-43. doi: 10.1093/jac/9.suppl_c.239.
2
Comparison of the in-vitro activity of Sch 29482 with thirteen other beta-lactam antibiotics against Neisseria meningitidis and Neisseria gonorrhoeae (including penicillinase-producing isolates).Sch 29482与其他13种β-内酰胺类抗生素对脑膜炎奈瑟菌和淋病奈瑟菌（包括产青霉素酶菌株）的体外活性比较。
J Antimicrob Chemother. 1982 Feb;9 Suppl C:175-80. doi: 10.1093/jac/9.suppl_c.175.
3
Prediction of antimeningococcic chemoprophylactic efficacy.抗脑膜炎球菌化学预防效果的预测
J Infect Dis. 1971 Feb;123(2):125-33. doi: 10.1093/infdis/123.2.125.
4
Antibiotic prophylaxis of carriers of sulfadiazine-resistant meningococci.对磺胺嘧啶耐药脑膜炎球菌携带者进行抗生素预防。
J Infect Dis. 1966 Oct;116(4):473-80. doi: 10.1093/infdis/116.4.473.
5
Effectiveness of rifampin in eradicating the meningococcal carrier state in a relatively closed population: emergence of resistant strains.
J Infect Dis. 1971 Aug;124(2):172-8. doi: 10.1093/infdis/124.2.172.
6
Rifampin. Levels in serum and saliva and effect on the meningococcal carrier state.利福平。血清和唾液中的水平及其对脑膜炎球菌携带状态的影响。
JAMA. 1970 Nov 9;214(6):1055-9. doi: 10.1001/jama.214.6.1055.
7
Attempted prophylaxis against meningococcal infection using intramuscular penicillin.尝试使用肌内注射青霉素预防脑膜炎球菌感染。
Mil Med. 1967 Dec;132(12):1009-11.
8
Effect of rifampin and minocycline on meningococcal carrier rates.利福平与米诺环素对脑膜炎球菌带菌率的影响。
J Infect Dis. 1971 Aug;124(2):199-205. doi: 10.1093/infdis/124.2.199.
9
Side effects of minocycline: a double-blind study.米诺环素的副作用：一项双盲研究。
Antimicrob Agents Chemother. 1977 Apr;11(4):712-7. doi: 10.1128/AAC.11.4.712.
Zotero 插件