地高辛在锂存在情况下的药效学与药代动力学。
Pharmacodynamics and pharmacokinetics of digoxin in the presence of lithium.
作者信息
Cooper S J, Kelly J G, Johnston G D, Copeland S, King D J, McDevitt D G
出版信息
Br J Clin Pharmacol. 1984 Jul;18(1):21-5. doi: 10.1111/j.1365-2125.1984.tb05016.x.
Abstract
Previous biochemical and clinical data suggest there may be an interaction between digoxin and lithium. The pharmacodynamics and pharmacokinetics of an intravenous infusion of digoxin were studied in six male subjects before and after 2 weeks treatment with lithium carbonate. The effects of lithium on sodium pump activity, intracellular electrolytes and extracellular electrolytes were studied. No significant interaction between digoxin and lithium was found. No significant effects of lithium on sodium pump activity or electrolyte concentrations were found.
摘要
先前的生化和临床数据表明，地高辛和锂之间可能存在相互作用。在6名男性受试者接受碳酸锂治疗2周前后，研究了静脉输注地高辛的药效学和药代动力学。研究了锂对钠泵活性、细胞内电解质和细胞外电解质的影响。未发现地高辛和锂之间存在显著相互作用。未发现锂对钠泵活性或电解质浓度有显著影响。
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