单核细胞增生李斯特菌脂质对小鼠淋巴细胞的体外作用。
The effect of Listeria monocytogenesis lipids on the mouse lymphocytes in vitro.
作者信息
Jakoniuk P, Borowski J
出版信息
Arch Immunol Ther Exp (Warsz). 1980;28(4):603-9.
The effect of Listeria monocytogenes lipids (LML) on the incorporation of 3H-thymidine into mouse spleen lymphocytes cultured in vitro was studied. It has been found that LML was mitogenic for B lymphocytes but did not stimulate T lymphocytes. The presence of autologous T dependent cells did not change the intensity of B lymphocytes stimulation of LML. However, macrophages markedly increased the effect of LML on B lymphocytes. The supernatants of the cultures of unfractionated spleen lymphocytes stimulated with LML, contrary to those stimulated with PHA, did not inhibit the macrophage migration. It has been concluded that LML is an unspecific B lymphocyte mitogen.
研究了单核细胞增生李斯特菌脂质（LML）对体外培养的小鼠脾淋巴细胞掺入³H-胸腺嘧啶核苷的影响。已发现LML对B淋巴细胞有促有丝分裂作用，但不刺激T淋巴细胞。自体T辅助细胞的存在并未改变LML对B淋巴细胞的刺激强度。然而，巨噬细胞显著增强了LML对B淋巴细胞的作用。与用PHA刺激的培养物上清液相反，用LML刺激的未分离脾淋巴细胞培养物上清液不抑制巨噬细胞迁移。得出的结论是，LML是一种非特异性B淋巴细胞促有丝分裂原。
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