抗原Nou。一种新的高频Rh抗原。

Antigen Nou. A new high frequency Rh antigen.

作者信息

Habibi B, Perrier P, Salmon C

出版信息

Rev Fr Transfus Immunohematol. 1981 Feb;24(1):117-20. doi: 10.1016/s0338-4535(81)80032-3.

Abstract

Serum from a D--/D-- allo-immunized woman is found to contain 3 separable antibodies: anti-e, anti-Ee (Rh 17) and a third component which, in contrast to 5 other sera from people with Rh deleted phenotypes, reacts strongly with red blood cells from Mrs Nou., a DIV(C)--/DIV(C)--black woman. The latter component studied by elution and coagglutination using Nou. cells reacts with a hitherto unrecognized public antigen within the Rh system. 2750 random donors, 2Rh mod. individuals and 17 people with public minus phenotypes in other blood group systems were found to express the antigen. 2 Dc--/Dc--, 4 D--/D-- and 4 Rh nul samples were non reactive. The identity of the antibody with anti-Hr (Rh 18) was ruled out since the original anti-Hr failed to react with Nou. red blood cells.

摘要

在一名D--/D--同种免疫女性的血清中发现含有3种可分离的抗体：抗 - e、抗 - Ee（Rh 17）以及第三种成分。与其他5名具有Rh缺失表型的人的血清不同，该成分与一名DIV(C)--/DIV(C)--黑人女性努夫人的红细胞发生强烈反应。通过使用努夫人的细胞进行洗脱和凝聚反应研究后发现，后一种成分与Rh系统中一种迄今未被识别的公共抗原发生反应。在2750名随机献血者、2名Rh变异型个体以及其他血型系统中17名具有公共抗原阴性表型的人中发现了该抗原的表达。2份Dc--/Dc--、4份D--/D--和4份Rh无细胞样本无反应。由于最初的抗 - Hr不能与努夫人的红细胞发生反应，所以排除了该抗体与抗 - Hr（Rh 18）的一致性。