Brzeźnicka E A, Chmielnicka J
Environ Health Perspect. 1981 Jun;39:131-42. doi: 10.1289/ehp.39-1568742.
The effect of sodium selenite administered intragastrically in repeated doses to rats receiving ethylmercuric chloride po in various repeated doses (0.25 or 2.5 mg Hg/kg) on the excretion, whole-body retention, and organ distribution of mercury was studied. Selenium was found to affect the distribution of ethylmercury among tissues and subcellular fractions of the kidneys and liver as well as its binding to proteins of soluble fractions in these organs. Similarities and differences between the effect of interaction of sodium selenite with ethylmercuric chloride and methylmercury as well as inorganic mercury are also discussed.
研究了在大鼠经口给予不同重复剂量(0.25或2.5毫克汞/千克)的氯化乙基汞时,重复经胃给予亚硒酸钠对汞的排泄、全身潴留及器官分布的影响。发现硒会影响乙基汞在肾脏和肝脏的组织及亚细胞组分中的分布,以及其与这些器官可溶性组分中蛋白质的结合。还讨论了亚硒酸钠与氯化乙基汞相互作用的效应与甲基汞以及无机汞的效应之间的异同。