Babeş V T, Tănase M, Cepănaru S, Cepănaru R
Virologie. 1981 Apr-Jun;32(2):93-8.
The presence of HBeAg and anti-HBe was investigated in 1,088 serum samples from 436 patients with HBsAg-positive acute viral hepatitis. The prevalence of HBeAg in the initial serum samples (collected upon hospital admission) was of 37.47%. In view of the results obtained with serial serum samples collected at 1-week-intervals the patients could be grouped into 4 categories: 1) seroconversion; 2) persistence of HBeAg; 3) presence of anti-HBe and 4) other serological sequences, irregular as compared with the former ones. Some serological characteristics point to a similar pathogenic behaviour in the first 3 categories, distinct from that of the patients belonging to the 4th category; the difference is ascribed to deficiencies in the immune response to hepatitis B virus antigens.
对436例HBsAg阳性急性病毒性肝炎患者的1088份血清样本进行了HBeAg和抗-HBe检测。初始血清样本（入院时采集）中HBeAg的流行率为37.47%。根据每隔1周采集的系列血清样本所获结果，患者可分为4类：1）血清转换；2）HBeAg持续存在；3）抗-HBe存在；4）其他血清学序列，与前三者相比不规律。一些血清学特征表明前3类患者具有相似的致病行为，与第4类患者不同；这种差异归因于对乙肝病毒抗原免疫反应的缺陷。
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