Mongin P
Br Poult Sci. 1978 Jul;19(4):501-9. doi: 10.1080/00071667808416506.
The effect of acetazolamide, an inhibitor of carbonic anhydrase activity, on the intracellular composition of the shell gland mucosa was determined. The normal cyclic hydration of the mucosal cells was found to be reduced when the egg was in the uterus and the partition of the water between the intra- and extracellular compartments was modified. Acetazolamide decreased the accumulation of Na+ within the cells, inhibited the Na+-independent movement of Cl- and reduced the transfer of Cl- linked with Na+. It is concluded that acetazolamide blocks the intracellular generation of HCO3- and the reabsorption of Cl-.
测定了碳酸酐酶活性抑制剂乙酰唑胺对壳腺黏膜细胞内成分的影响。发现当卵在子宫中时，黏膜细胞正常的周期性水合作用降低，细胞内和细胞外间隙之间的水分分配发生改变。乙酰唑胺减少了细胞内Na+的积累，抑制了Cl-的非Na+依赖性转运，并减少了与Na+相关的Cl-转运。得出的结论是，乙酰唑胺阻断了细胞内HCO3-的生成和Cl-的重吸收。
