N-甲酰亚胺硫霉素对庆大霉素耐药铜绿假单胞菌的活性更强。
Superior activity of N-formimidoyl thienamycin against gentamicin-resistant Pseudomonas aeruginosa.
作者信息
Michael P R, Alford R H, McGee Z A
出版信息
Antimicrob Agents Chemother. 1981 Nov;20(5):702-4. doi: 10.1128/AAC.20.5.702.
Abstract
N-Formimidoyl thienamycin (N-F-thienamycin), cefotaxime, moxalactam, and cefsulodin were tested by agar dilution against 125 isolates of Pseudomonas aeruginosa, Serratia marcescens, Klebsiella pneumoniae, and Providencia stuartii. Against gentamicin-susceptible P. aeruginosa, N-F-thienamycin and cefsulodin were most active. Only N-F-thienamycin inhibited gentamicin-resistant P. aeruginosa at less than or equal to 4 microgram/ml. N-F-thienamycin's activity equaled or surpassed that of the other antibiotics tested against both the gentamicin-susceptible and -resistant Enterobacteriaceae.
摘要
采用琼脂稀释法，对125株铜绿假单胞菌、粘质沙雷氏菌、肺炎克雷伯菌和斯氏普罗威登斯菌进行了N-甲脒基硫霉素（N-F-硫霉素）、头孢噻肟、拉氧头孢和头孢磺啶的药敏试验。对于对庆大霉素敏感的铜绿假单胞菌，N-F-硫霉素和头孢磺啶活性最强。只有N-F-硫霉素在浓度小于或等于4微克/毫升时可抑制对庆大霉素耐药的铜绿假单胞菌。N-F-硫霉素对庆大霉素敏感和耐药的肠杆菌科细菌的活性等于或超过了所测试的其他抗生素。
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