Hull M G, Savage P E, Bromham D R
Br Med J (Clin Res Ed). 1982 Jun 5;284(6330):1681-5. doi: 10.1136/bmj.284.6330.1681.
A simplified scheme for the management of anovulatory and of ovulatory (usually called unexplained) infertility was evaluated in 244 women. Eighteen patients were excluded because of primary ovarian failure, 164 were treated for ovulatory failure, and 62 with ovulatory infertility remained untreated. Twenty-five patients had a properly validated negative postcoital test. In the remaining 201 patients the two-year conception rates were 96% in patients with amenorrhoea, 83% in those with oligomenorrhoea, 74% in those with luteal deficiency, and 88% in those with ovulatory infertility. Comparison with normal rates implied that amenorrhoea represents a pure form of ovulatory failure that is completely correctable whereas in other conditions unexplained factors also contribute to infertility though to a much smaller extent than was previously thought.
对244名女性评估了一种简化的无排卵性和排卵性(通常称为不明原因性)不孕症管理方案。18名患者因原发性卵巢功能衰竭被排除,164名患者接受了排卵功能衰竭治疗,62名排卵性不孕症患者未接受治疗。25名患者性交后试验结果经适当验证为阴性。在其余201名患者中,闭经患者的两年受孕率为96%,月经过少患者为83%,黄体功能不全患者为74%,排卵性不孕症患者为88%。与正常受孕率相比表明,闭经代表一种完全可纠正的纯粹排卵功能衰竭形式,而在其他情况下,不明原因因素也导致不孕,尽管其程度比之前认为的要小得多。