干燥综合征中SS - B沉淀抗体的预测价值。
Predictive value of SS-B precipitating antibodies in Sjoögren's syndrome.
作者信息
Isenberg D A, Hammond L, Fisher C, Griffiths M, Stewart J, Bottazzo G F
出版信息
Br Med J (Clin Res Ed). 1982 Jun 12;284(6331):1738-40. doi: 10.1136/bmj.284.6331.1738.
As part of a screening programme several patients were identified with antibodies to the nuclear antigen SS-B. Fifteen were examined and 11 found to have Sjögren's syndrome, though this had not been suspected by most of the referring physicians. In contrast, among a group of 17 patients with overt Sjögren's syndrome, most of whom also had rheumatoid arthritis, only one had antibodies to SS-B. Patients presenting with polyarthralgia found to be SS-B positive may be likely to develop Sjögren's syndrome but unlikely to develop rheumatoid arthritis. The detection of SS-B antibodies may antedate clinical evidence of Sjögren's syndrome by months or even years. These results emphasise the clinical heterogeneity of Sjögren's syndrome.
作为一项筛查计划的一部分，数名患者被检测出含有抗核抗原SS - B的抗体。对15名患者进行了检查，其中11名被诊断患有干燥综合征，尽管大多数转诊医生之前并未怀疑。相比之下，在一组17名患有明显干燥综合征的患者中（其中大多数还患有类风湿性关节炎），只有1名患者含有抗SS - B抗体。表现为多关节痛且被检测出SS - B呈阳性的患者可能会发展为干燥综合征，但不太可能发展为类风湿性关节炎。SS - B抗体的检测可能比干燥综合征的临床证据早出现数月甚至数年。这些结果强调了干燥综合征的临床异质性。
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