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[单次注射肝癌致癌物4-二甲基氨基偶氮苯及其非致癌类似物后大鼠肝脏中色氨酸吡咯酶活性的变化]

[Changes in tryptophan pyrrolase activity in the rat liver after a single injection of the hepatocarcinogen 4-dimethylaminoazobenzene and its noncarcinogenic analog].

作者信息

Chernysheva M D, Medvedeva N D

出版信息

Tsitologiia. 1982 May;24(5):615-7.

PMID:6808731
Abstract

A single injection of hepatocarcinogen 4-dimethylaminoazobenzene in rats results in considerable changes of tryptophanpyrrolase of the liver. A non-carcinogenic analog 4-diethylaminoazobenzene causes similar, although a milder shift. The observed injury of definitive hepatocytes and proliferation of oval and transition cells, due to the toxic effect of both the agents, may be one of the causes of changes in tryptophan pyrrolase activity.

摘要

给大鼠单次注射肝癌致癌物4-二甲基氨基偶氮苯会导致肝脏色氨酸吡咯酶发生显著变化。非致癌类似物4-二乙氨基偶氮苯也会引起类似变化，不过程度较轻。由于这两种物质的毒性作用，所观察到的成熟肝细胞损伤以及卵圆细胞和过渡细胞的增殖，可能是色氨酸吡咯酶活性变化的原因之一。

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