Mann W, Wannenmacher M, Beck C, Laniado K
Laryngol Rhinol Otol (Stuttg). 1982 Aug;61(8):441-4.
Taking into account the death rate of all other causes for that age group and comparing the survival time and the recurrence rate in patients with preoperative short-time irradiation with telecobalt 60 and a focal dose of 20 Gy with a second group of patients treated with postoperative radiotherapy, we were unable to detect any advantage of the so-called "sandwich therapy" in cancer of the tonsils, the base of the tongue or the hypopharynx. On the contrary: patients with "sandwich therapy" had to be hospitalized longer because of the interval between preoperative radiotherapy and surgery and because of the delay in restoring postoperative speech and deglutition.
考虑到该年龄组所有其他病因的死亡率,并将术前采用钴60短时间照射且局部剂量为20 Gy的患者的生存时间和复发率与第二组接受术后放疗的患者进行比较,我们未能发现所谓的“三明治疗法”在扁桃体癌、舌根癌或下咽癌治疗中具有任何优势。相反,接受“三明治疗法”的患者因术前放疗与手术之间的间隔以及术后言语和吞咽功能恢复延迟而需要更长时间住院。