抗坏血酸对哮喘患者对乙酰甲胆碱激发试验反应的影响。

Effect of ascorbic acid on response to methacholine challenge in asthmatic subjects.

作者信息

Mohsenin V, Dubois A B, Douglas J S

出版信息

Am Rev Respir Dis. 1983 Feb;127(2):143-7. doi: 10.1164/arrd.1983.127.2.143.

DOI:10.1164/arrd.1983.127.2.143

Abstract

We studied the effect of ascorbic acid in 14 mild asthmatic subjects. The effect of ascorbic acid (1.0 g orally) was assessed by the changes in concentration of methacholine required to decrease the specific airway conductance by 40% (pD40). Ascorbic acid increased pD40 from control values of 9.38 +/- 1.97 mg/ml (mean +/- SEM) to 12.59 mg/ml +/- 2.52 (p less than 0.05). Administration of 50 mg of indomethacin, orally, reversed the effect of ascorbic acid. Indomethacin alone had no effect on the mean pD40. The results suggest that ascorbic acid exerts its effect via alteration of arachidonic acid metabolism.

摘要

我们研究了抗坏血酸对14名轻度哮喘患者的影响。通过降低特定气道传导率40%（pD40）所需的乙酰甲胆碱浓度变化来评估抗坏血酸（口服1.0克）的效果。抗坏血酸使pD40从对照值9.38±1.97毫克/毫升（平均值±标准误）增加到12.59毫克/毫升±2.52（p<0.05）。口服50毫克吲哚美辛可逆转抗坏血酸的作用。单独使用吲哚美辛对平均pD40无影响。结果表明，抗坏血酸通过改变花生四烯酸代谢发挥作用。