类风湿关节炎中血清趋化能力缺陷

Defective serum chemotactic capacity in rheumatoid arthritis.

作者信息

Attia W M, Ali M K, Abu-Ghazalah L M, Shams A H, Clark H W, Brown T M, Bellanti J A

出版信息

Ann Allergy. 1983 Apr;50(4):266-70.

Abstract

Polymorphonuclear leukocytes (PMN) chemotaxis and serum chemoattractant ability were studied in patients with rheumatoid arthritis (RA) employing the agarose plate technique. No statistically significant differences were observed in random migration of unstimulated cells compared to the controls. Moreover, there were no statistically significant differences between the chemotactic migration of control and patient cells in response to a number of non-treated sera. The chemotactic responsiveness of normal PMN cells to treated rheumatoid serum was significantly less than that observed using treated control serum with Escherichia coli lipopolysaccharide. The possible explanation for this abnormality may be due to the presence of chemotactic inhibitors in some RA serum. No correlation was detected between chemoattractant activity of rheumatoid arthritis serum, circulating immune complexes or rheumatoid factor. There were no statistically significant differences in the adhesiveness of RA-PMNs compared to normal PMNs.

摘要

采用琼脂糖平板技术研究了类风湿性关节炎（RA）患者的多形核白细胞（PMN）趋化性和血清趋化因子能力。与对照组相比，未刺激细胞的随机迁移未观察到统计学上的显著差异。此外，在许多未处理血清刺激下，对照细胞和患者细胞的趋化迁移之间也没有统计学上的显著差异。正常PMN细胞对处理过的类风湿血清的趋化反应性明显低于使用经大肠杆菌脂多糖处理的对照血清时观察到的反应性。这种异常的可能解释可能是某些RA血清中存在趋化抑制剂。类风湿性关节炎血清的趋化活性、循环免疫复合物或类风湿因子之间未检测到相关性。与正常PMN相比，RA-PMN的黏附性没有统计学上的显著差异。