庆大霉素持续两天恒速输注后在大鼠内淋巴和外淋巴中的情况。
Gentamicin persistence in rat endolymph and perilymph after a two-day constant infusion.
作者信息
Tran Ba Huy P, Meulemans A, Wassef M, Manuel C, Sterkers O, Amiel C
出版信息
Antimicrob Agents Chemother. 1983 Feb;23(2):344-6. doi: 10.1128/AAC.23.2.344.
Abstract
The kinetics of gentamicin in the inner ear fluids of rats were studied up to 15 days after cessation of a 2-day constant infusion of 10 micrograms/min. In endolymph, the concentration of gentamicin persisted at about 1 microgram/ml for up to 15 days, precluding the determination of the half-life of the drug in this fluid. In perilymph, gentamicin cleared more slowly than after a shorter period of infusion. These results suggest that the tissues of the inner ear could bind the aminoglycoside and then slowly release it into the surrounding fluids.
摘要
在以10微克/分钟的速度持续输注2天停止后，对大鼠内耳液中庆大霉素的动力学进行了长达15天的研究。在内淋巴中，庆大霉素的浓度在长达15天的时间里一直维持在约1微克/毫升，这使得无法测定该药物在这种液体中的半衰期。在外淋巴中，庆大霉素清除的速度比短时间输注后更慢。这些结果表明，内耳组织可能会结合氨基糖苷类药物，然后缓慢地将其释放到周围的液体中。
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