Shuin T, Nishimura R, Noda K, Umeda M, Ono T
Gan. 1983 Feb;74(1):100-5.
A vitamin A analog, 13-cis-retinoic acid (13-cis-RA), was tested for effect on intercellular metabolic cooperation between 6-thioguanine-resistant and -sensitive V79 Chinese hamster cells. Most typical tumor promoters have been reported to inhibit metabolic cooperation. 13-cis-RA was found to enhance metabolic cooperation of cells treated with a potent tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate. However, inhibition of metabolic cooperation was noticed when 13-cis-RA was used at higher concentrations.
一种维生素A类似物，13-顺式视黄酸（13-cis-RA），被测试其对6-硫代鸟嘌呤抗性和敏感的V79中国仓鼠细胞之间细胞间代谢合作的影响。据报道，大多数典型的肿瘤促进剂会抑制代谢合作。发现13-顺式视黄酸可增强用强效肿瘤促进剂12-O-十四烷酰佛波醇-13-乙酸酯处理的细胞的代谢合作。然而，当使用较高浓度的13-顺式视黄酸时，会注意到代谢合作受到抑制。
