抗胆碱酯酶药物中毒时脑儿茶酚胺代谢变化与体温过低

Brain catecholamine metabolism changes and hypothermia in intoxication by anticholinesterase agents.

作者信息

Coudray-Lucas C, Prioux-Guyonneau M, Sentenac H, Cohen Y, Wepierre J

出版信息

Acta Pharmacol Toxicol (Copenh). 1983 Mar;52(3):224-9. doi: 10.1111/j.1600-0773.1983.tb01090.x.

DOI:10.1111/j.1600-0773.1983.tb01090.x

Abstract

Sublethal doses of physostigmine, paraoxon and soman induce a short-lasting fall in rat core temperature potentiated by alpha-methyl-para-tyrosine (alpha-MT) (early effects). When the own hypothermic effect of the anticholinesterase agent has disappeared (late effects), alpha-MT induces a new decrease in temperature. Parallel biochemical studies of catecholamine levels and turnover were performed in several brain areas. The norepinephrine (NE) turnover is generally increased particularly in the hypothalamus, suggesting that NE hypothalamic changes might be linked to a latent perturbation of thermoregulatory mechanisms. Furthermore, it was shown that soman acts differently from the other drugs by inducing quite important changes in both NE and dopamine levels.

摘要

亚致死剂量的毒扁豆碱、对氧磷和梭曼会引起大鼠核心体温短暂下降，α-甲基对酪氨酸（α-MT）可增强这种下降（早期效应）。当抗胆碱酯酶药物自身的体温过低效应消失后（晚期效应），α-MT会引起体温再次下降。同时对几个脑区进行了儿茶酚胺水平和周转率的生化研究。去甲肾上腺素（NE）周转率普遍增加，尤其是在下丘脑，这表明下丘脑NE的变化可能与体温调节机制的潜在紊乱有关。此外，研究表明梭曼与其他药物的作用不同，它会引起NE和多巴胺水平的显著变化。