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[心肌的能量平衡及其抗心律失常药物校正]

[Energy balance of the myocardium and its correction using antiarrhythmics].

作者信息

Shlygin V V

出版信息

Biofizika. 1983 Mar-Apr;28(2):311-4.

PMID:6849995
Abstract

Changes in energetic balance (chi) during the transition of myocardium from norm to hypoxia and under antiarrhythmics effect were analysed on a mathematical model of the heart ventricle band. (chi-useful work/consumed energy ratio. Orciprenalin was shown to increase chi in the state close to the norm; quinidine, bretilium, procainamide, propranalol increase chi only under hypoxia; varapamile, as well as lidocain when it improves conduction ought to be effective for each initial (before therapy) state of the myocardium.

摘要

在心室带心脏数学模型上分析了心肌从正常状态转变为缺氧状态以及在抗心律失常药物作用下能量平衡(气)的变化。(气——有用功/消耗能量比。已表明奥西那林在接近正常状态时会增加气;奎尼丁、溴苄铵、普鲁卡因胺、普萘洛尔仅在缺氧时增加气;维拉帕米以及利多卡因在改善传导时对心肌的每个初始(治疗前)状态都应该是有效的。

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