Ignat'eva E N, Kriuchkova G S, Kotova O I, Ostrovskiĭ V Iu, Agafonov B V
Zh Nevropatol Psikhiatr Im S S Korsakova. 1978;78(7):1043-50.
On the basis of a clinico-morphological analysis of 50 cases with acute respiratory viral infections, developing clinically with brain symptoms, the authors distinguish 2 main factors, influencing their development. The main factors consist in a evicious circles of respiratory disorders which causes the appearance of toxico-hypoxic encephalopathy. Encephalitis of an immuno-allergic nature are seen less frequently and may appear soon after acute respiratory viral infections. Histologically there are 2 forms of allergic encephalitis: 1) with perivascular lymphocyte infiltration and 2) hemorrhagical. The second form differs clinically from the first by apoplectic-like development with a coma and rapid short course. Both forms of poctinfluenza allergic encephalitis differ from encephalopathy in the fact that they develop not during the crucial phase of acute respiratory infection, but follow 1-2 weeks. The morphological differences of hemmorrhagical forms of poctinfluenza allergic encephalitis from from encephalopathy are characterized by intensive perivascular hemorrhages with a tendency towards their fusion; by changes in the vascular walls; by an appearance of small foci of colliquative necrosis and demyelinization.
在对50例临床上出现脑部症状的急性呼吸道病毒感染病例进行临床形态学分析的基础上,作者区分出影响其发展的2个主要因素。主要因素在于呼吸紊乱的恶性循环,这会导致中毒性缺氧性脑病的出现。免疫过敏性脑炎较少见,可能在急性呼吸道病毒感染后不久出现。组织学上有2种过敏性脑炎形式:1)血管周围淋巴细胞浸润型和2)出血型。第二种形式在临床上与第一种不同,表现为类似中风的发展过程,伴有昏迷且病程迅速短暂。这两种流行性感冒过敏性脑炎形式与脑病的不同之处在于,它们不是在急性呼吸道感染的关键阶段发生,而是在1至2周后出现。流行性感冒过敏性脑炎出血型与脑病在形态学上的差异表现为血管周围密集出血并有融合倾向;血管壁改变;出现小的液化性坏死灶和脱髓鞘。