勒皮定的抗利什曼原虫活性。
The antileishmanial activity of lepidines.
作者信息
Kinnamon K E, Steck E A, Loizeaux P S, Hanson W L, Chapman W L, Waits V B
出版信息
Am J Trop Med Hyg. 1978 Jul;27(4):751-7. doi: 10.4269/ajtmh.1978.27.751.
PMID:686239
Abstract
A series of lepidines (6-methoxy-4-methyl-8-aminoquinoline derivatives) was studied in a hamster-Leishmania donovani model. Members of this class were found to have activity many-fold that of the standard, meglumine antimoniate (Glucantime). One of them, 8-(6-diethylamino-hexylamino)-6-methoxy-4-methylquinoline, designated WR 6026, when given orally was over 700 times as effective as the standard antimonial drug.
摘要
在仓鼠-杜氏利什曼原虫模型中对一系列的勒皮定（6-甲氧基-4-甲基-8-氨基喹啉衍生物）进行了研究。发现该类成员的活性比标准药物葡甲胺锑酸盐（葡糖胺锑）高许多倍。其中一种，8-(6-二乙氨基己基氨基)-6-甲氧基-4-甲基喹啉，命名为WR 6026，口服时的效果比标准抗锑药物高700倍以上。
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