Zhang W G
Sci Sin B. 1983 Apr;26(4):374-80.
In this paper, a new method is suggested for calculating the absorption amount of drug. The method is based on the general linear compartment model for pharmacokinetics, hence applicable to any proper linear compartment model for pharmacokinetics. For the linear one compartment model, it is in agreement with the Wagner-Nelson method which is often used nowadays. For the linear two compartment model, it has advantages over the Loo-Riegelman method, which is also in common use in, for example, simplicity in mathematical derivation, less computation, etc. And it can be easily extended to some particular nonlinear compartment model.
本文提出了一种计算药物吸收量的新方法。该方法基于药代动力学的通用线性房室模型,因此适用于任何合适的药代动力学线性房室模型。对于线性一室模型,它与目前常用的Wagner-Nelson方法一致。对于线性二室模型,它比Loo-Riegelman方法具有优势,例如在数学推导简单、计算量小等方面,Loo-Riegelman方法也是常用的。并且它可以很容易地扩展到一些特定的非线性房室模型。