诱导对细菌脂多糖无反应的小鼠产生口服耐受。

Induction of oral tolerance in mice unresponsive to bacterial lipopolysaccharide.

作者信息

Saklayen M G, Pesce A J, Pollak V E, Michael J G

出版信息

Infect Immun. 1983 Sep;41(3):1383-5. doi: 10.1128/iai.41.3.1383-1385.1983.

DOI:10.1128/iai.41.3.1383-1385.1983

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC264653/

Abstract

C3H/HeJ lipopolysaccharide (LPS)-unresponsive and closely related C3H/HeSn LPS-responsive mice were rendered tolerant to hen albumin by antigen feeding before parenteral immunization. Both single and multiple feedings of antigen were effective in inducing tolerance to hen albumin in LPS-responsive and -unresponsive strains of mice. Our data demonstrate that ability to respond to LPS is not a prerequisite for induction of oral tolerance to a soluble protein antigen.

摘要

C3H/HeJ 脂多糖（LPS）无反应性且密切相关的 C3H/HeSn LPS 反应性小鼠，在经肠道外免疫前通过喂食抗原使其对鸡白蛋白产生耐受。单次和多次喂食抗原在诱导 LPS 反应性和无反应性小鼠品系对鸡白蛋白产生耐受方面均有效。我们的数据表明，对 LPS 作出反应的能力并非诱导对可溶性蛋白质抗原产生口服耐受的先决条件。

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本文引用的文献

1

PASSIVE CUTANEOUS ANAPHYLAXIS.被动皮肤过敏反应

Methods Med Res. 1964;10:158-62.

2

Lack of oral tolerance in C3H/HeJ mice.C3H/HeJ小鼠中缺乏口服耐受。

J Exp Med. 1982 Feb 1;155(2):605-10. doi: 10.1084/jem.155.2.605.

3

Lipopolysaccharide (LPS) regulation of the immune response: LPS converts germfree mice to sensitivity to oral tolerance induction.脂多糖（LPS）对免疫反应的调节：LPS可使无菌小鼠转变为对口服耐受诱导敏感。

J Immunol. 1982 Sep;129(3):959-65.

4

Lipopolysaccharide (LPS) regulation of the immune response: LPS influence on oral tolerance induction.脂多糖（LPS）对免疫反应的调节：LPS对口服耐受诱导的影响。

J Immunol. 1982 May;128(5):1992-8.

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Oral tolerance.口服耐受

Transplantation. 1980 May;29(5):353-6. doi: 10.1097/00007890-198005000-00001.

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Activation of C3H/HeJ macrophages by endotoxin.内毒素对C3H/HeJ巨噬细胞的激活作用。

J Immunol. 1980 Nov;125(5):2189-94.

7

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Eur J Immunol. 1982 Sep;12(9):767-73. doi: 10.1002/eji.1830120912.

8

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Infect Immun. 1972 Jan;5(1):107-13. doi: 10.1128/iai.5.1.107-113.1972.

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