在亚慢性喂养研究中，次氮基三乙酸诱导大鼠产生肾毒性的可逆性。

Reversibility of nephrotoxicity induced in rats by nitrilotriacetate in subchronic feeding studies.

作者信息

Myers M C, Kanerva R L, Alden C L, Anderson R L

出版信息

Food Chem Toxicol. 1982 Dec;20(6):925-34. doi: 10.1016/s0015-6264(82)80230-7.

Abstract

The reversibility of nitrilotriacetate (NTA)-associated nephrotoxicity was investigated by comparing renal tissues from rats fed nephrotoxic levels of NTA for 7 wk with those from rats allowed 5 wk of recovery after the 7-wk exposure. In addition the toxicity of 2% Na3NTA X H2O in the diet (73 mumol/g diet) was compared with that of 1.5% H3NTA (79 mumol/g diet). The two forms of NTA induced comparable renal tubular cell toxicity which was characterized by proximal convoluted cell vacuolation and hyperplasia. These effects were noted in all of the exposed animals although the extent of damage varied. This specific renal tubular cell toxicity was completely reversed during the 5-wk recovery period. Renal pelvic transitional cell toxicity was induced primarily by Na3NTA X H2O. Renal pelvic toxicity was characterized by hydronephrosis, and erosion, ulceration and hyperplasia of the transitional epithelium. All forms of renal toxicity except that accompanying hydronephrosis were reversed when Na3NTA X H2O feeding was discontinued.

摘要

通过比较喂食肾毒性水平的次氮基三乙酸（NTA）7周的大鼠与在7周暴露后给予5周恢复期的大鼠的肾组织，研究了NTA相关肾毒性的可逆性。此外，还比较了饮食中2%的三水合次氮基三乙酸三钠（Na3NTA·H2O，73微摩尔/克饮食）与1.5%的次氮基三乙酸（H3NTA，79微摩尔/克饮食）的毒性。两种形式的NTA诱导了相当的肾小管细胞毒性，其特征为近曲小管细胞空泡化和增生。尽管损伤程度不同，但在所有暴露动物中均观察到了这些效应。这种特定的肾小管细胞毒性在5周的恢复期内完全逆转。肾盂移行细胞毒性主要由三水合次氮基三乙酸三钠诱导。肾盂毒性的特征为肾积水以及移行上皮的糜烂、溃疡和增生。当停止喂食三水合次氮基三乙酸三钠时，除肾积水外的所有形式的肾毒性均得到逆转。