[Biliary excretion kinetics of the biliary contrast media ioglycamide, iodoxamate and iotroxamate in the dog].

The biliary excretion of meglumine iotroxamate (ITX) and meglumine iodoxamate (IDX), two new intravenous cholangiographic contrast materials, was compared with that of meglumine ioglycamide (IGL) in bile-fistula dogs following intravenous infusion in a steady state. With any equimolar infusion rate or plasma concentration, more ITX and IDX were secreted in the bile than IGL. The maximum rate of biliary excretion (Emax.) of either ITX (2.23 +/- SD 0.28 mumol/min/kg) or IDX (2.91 +/- SD 0.39 mumol/min/kg) was significantly greater than that of IGL (1.22 +/- SD 0.19 mumol/min/kg); the biliary concentration was always greater for ITX and IDX than for IGL.