来自小单孢菌属的新型蒽环类糖苷。II. 分离、表征及生物学特性

New anthracycline glycosides from Micromonospora. II. isolation, characterization and biological properties.

作者信息

Cassinelli G, Di Matteo F, Forenza S, Ripamonti M C, Rivola G, Arcamone F, Di Marco A, Casazza A M, Soranzo C, Pratesi G

出版信息

J Antibiot (Tokyo). 1980 Dec;33(12):1468-73. doi: 10.7164/antibiotics.33.1468.

DOI:10.7164/antibiotics.33.1468

PMID:6941955

Abstract

Four glycosides, designated A, B, C and D, are the main components of the anthracycline complex produced by cultures of Micromonospora sp. nov. They were extracted by solvent partition, separated by column chromatography and characterized by chemical and physical methods as 11-deoxy analogues of daunorubicin. Among these new anthracyclines, displaying antibacterial and cytotoxic activity in vitro, 11-deoxydaunorubicin and 11-deoxydoxorubicin are also active against P388 leukemia in mice.

摘要

四种糖苷，分别命名为A、B、C和D，是新小单孢菌（Micromonospora sp. nov.）培养物产生的蒽环类复合物的主要成分。它们通过溶剂分配法提取，经柱色谱分离，并通过化学和物理方法鉴定为柔红霉素的11-脱氧类似物。在这些体外具有抗菌和细胞毒性活性的新型蒽环类药物中，11-脱氧柔红霉素和11-脱氧阿霉素对小鼠P388白血病也有活性。