非特异性力和有限受体数量对配体与细胞结合受体相互作用速率常数的影响。
Effect of nonspecific forces and finite receptor number on rate constants of ligand--cell bound-receptor interactions.
作者信息
DeLisi C, Wiegel F W
出版信息
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5569-72. doi: 10.1073/pnas.78.9.5569.
Abstract
We develop a theory of ligand diffusion in the presence of a central potential toward or away from receptor patches that are uniformly distributed over a spherical cell. The current onto the receptors is reduced to less than that onto the sphere by a factor that is a nonlinear function of the number of free receptors, their size, and their potential energy. Similarly, under conditions defined by the theory, the dissociation rate from a receptor is reduced by the probability of rebinding to some other receptor on the same cell. This complicates the kinetic analysis, leading to the possibility of an occupancy-dependent dissociation rate, but has no effect on the interpretation of thermodynamic data.
摘要
我们建立了一种配体在存在朝向或远离均匀分布于球形细胞表面的受体斑块的中心势场时的扩散理论。流向受体的电流相比于流向球体的电流减少了一个因子，该因子是游离受体数量、其大小及其势能的非线性函数。同样，在该理论所定义的条件下，受体的解离速率因重新结合到同一细胞上其他受体的概率而降低。这使得动力学分析变得复杂，导致解离速率可能依赖于占据情况，但对热力学数据的解释没有影响。
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