Strang C J, Siegel R C, Phillips M L, Poon P H, Schumaker V N
Proc Natl Acad Sci U S A. 1982 Jan;79(2):586-90. doi: 10.1073/pnas.79.2.586.
Electron micrographs are shown of the first component of human complement (C1) which has been crosslinked with a water-soluble carbodiimide to prevent dissociation into its C1q and C1r2C1s2 subunits. Two projections of the crosslinked molecule are seen in the electron micrographs, which are called "top" and "profile." In both views, the C1q heads are visible. From the top, the C1r2C1s2 tetrameric subunits appears to be located centrally on the C1q and folded to form a compact mass obscuring most of the arms and central bundle. In profile, the tetramer appears to be located in the region of the arms between the C1q heads and the central bundle. Both the heads and the rod-like central bundle appear to be free of C1r2C1s2 in these profile projections. Sometimes it is possible to count more than six domains in the region of the C1q heads, as though a portion of the tetramer had unfolded to protrude among the heads.
展示了人类补体（C1）第一成分的电子显微镜照片，该成分已与水溶性碳二亚胺交联，以防止解离成其C1q和C1r2C1s2亚基。在电子显微镜照片中可以看到交联分子的两个投影，分别称为“顶部”和“侧面”。在这两种视图中，C1q头部都是可见的。从顶部看，C1r2C1s2四聚体亚基似乎位于C1q的中央，并折叠形成一个紧凑的团块，遮住了大部分臂和中央束。从侧面看，四聚体似乎位于C1q头部和中央束之间的臂区域。在这些侧面投影中，头部和杆状中央束似乎都没有C1r2C1s2。有时在C1q头部区域可以数出六个以上的结构域，就好像四聚体的一部分展开并突出到头部之间。
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