15(S)-15-甲基前列腺素F2α的心血管效应
Cardiovascular effects of 15(S) 15 methyl-PGF2 alpha.
作者信息
Filippelli W, Filippelli A, Caloprice A, Vacca C, Bile G, Spadaro R, Marmo E
出版信息
J Med. 1982;13(5-6):387-98.
The effects of 15(S) 15-methyl-PGF2 alpha were studied on the cardiovascular system of dogs. Intravenous and intravertebral artery administration of 15(S)-methyl-PGF 2 alpha induced arterial hypertensive and respiratory effects more intense and longer lasting than those observed for PGF2 alpha. Intravenous administration of 15(S) 15-methyl-PGF2 alpha induced a decrease of vascular reactivity to 1-norepinephrine and 1-epinephrine and to carotidal occlusion. Infiltration of the carotid sinus walls with 15(S) 15-methyl-PGF2 alpha decreased the baroreceptor reactivity.
研究了15（S）-15-甲基前列腺素F2α对犬心血管系统的影响。静脉内和椎动脉内给予15（S）-甲基前列腺素F2α所引起的动脉高血压和呼吸效应比前列腺素F2α所观察到的效应更强烈且持续时间更长。静脉内给予15（S）-15-甲基前列腺素F2α可导致血管对去甲肾上腺素、肾上腺素以及颈动脉闭塞的反应性降低。用15（S）-15-甲基前列腺素F2α浸润颈动脉窦壁会降低压力感受器的反应性。
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