Kakumu S, Yata K, Kashio T
Gastroenterology. 1980 Oct;79(4):613-9.
The suppressor function of T cells separated from the peripheral blood lymphocytes of patients with acute or chronic liver disease was evaluated by using, as an indicator system, pokeweed mitogen-induced immunoglobulin synthesis in vitro. Suppressor activity of T cells was enhanced during the recovery phase in 13 or 17 patients who have recovered from acute viral hepatitis. When such T cells were irradiated before coculture, the suppressor function was selectively eliminated, but the helper T-cell function remained unchanged. In serial studies, normalization of the excess suppressor function of T cells was observed when the liver function of an acute viral hepatitis patient returned to the normal range. Except for chronic active liver disease, in which the suppressor activity of T cells was substantially reduced in 50% of the patients studied. the studies indicated normal T-cell functions, both suppressor and helper, in other liver diseases such as chronic persistent hepatitis, inactive cirrhosis, and fatty liver disease. These data sugest that the host immunoregulatory mechanism might be important in recovering from acute viral hepatitis and in perpetuating hepatocyte injury in chronic active liver disease.
通过使用体外商陆丝裂原诱导的免疫球蛋白合成作为指标系统，评估了从急性或慢性肝病患者外周血淋巴细胞中分离出的T细胞的抑制功能。在13名或17名从急性病毒性肝炎中康复的患者的恢复阶段，T细胞的抑制活性增强。当此类T细胞在共培养前受到照射时，抑制功能被选择性消除，但辅助性T细胞功能保持不变。在系列研究中，当急性病毒性肝炎患者的肝功能恢复到正常范围时，观察到T细胞过度抑制功能的正常化。除了慢性活动性肝病（在所研究的50%患者中T细胞抑制活性大幅降低）外，研究表明在其他肝病如慢性持续性肝炎、非活动性肝硬化和脂肪性肝病中，T细胞的抑制和辅助功能均正常。这些数据表明，宿主免疫调节机制可能在急性病毒性肝炎的恢复以及慢性活动性肝病中肝细胞损伤的持续存在中起重要作用。
