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植物凝集素植物血凝素和伴刀豆球蛋白A对带有IgG和IgM受体的人T细胞群体的作用。

The effect of the plant lectins phytohaemagglutinin and concanavalin A on human T cell populations bearing receptors for IgG and IgM.

作者信息

Gomez-Reino J, Habicht G S

出版信息

Clin Exp Immunol. 1980 Aug;41(2):372-9.

PMID:6969156
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537020/
Abstract

The effect of long-term culture with the plant lectins phytohaemagglutinin (PHA) and concanavalin A (con A) on the percentages of human T cells bearing Fc receptors for IgG (TG) and IgM (TM) was investigated. Con A produced an early increase in the percentage of TG cells as compared to control cells cultured without mitogen. TM cells decreased. PHA suppressed the percentages of both TG and TM. These changes were not due to loss of cell viability nor to loss of cell surface receptors in general since up to 98% of the cells continued to form sheep erythrocyte rosettes in the virtual absence of IgM Fc receptors.

摘要

研究了用植物凝集素植物血凝素（PHA）和刀豆球蛋白A（Con A）进行长期培养对携带IgG（TG）和IgM（TM）Fc受体的人T细胞百分比的影响。与未用有丝分裂原培养的对照细胞相比，Con A使TG细胞百分比早期增加。TM细胞减少。PHA抑制TG和TM的百分比。这些变化不是由于细胞活力丧失，也不是由于一般细胞表面受体丧失，因为在几乎没有IgM Fc受体的情况下，高达98%的细胞继续形成绵羊红细胞花环。

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The effect of the plant lectins phytohaemagglutinin and concanavalin A on human T cell populations bearing receptors for IgG and IgM.植物凝集素植物血凝素和伴刀豆球蛋白A对带有IgG和IgM受体的人T细胞群体的作用。
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本文引用的文献

1
Factors influencing the agglutinability of red cells: the demonstration of a variation in the susceptibility to agglutination exhibited by the red cells of individual oxen.影响红细胞凝集性的因素：个体牛红细胞对凝集敏感性差异的证明。
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Inhibitory and stimulatory effects of concanavalin A on the response of mouse spleen cell suspensions to antigen. II. Evidence for separate stimulatory and inhibitory cells.伴刀豆球蛋白A对小鼠脾细胞悬液对抗原反应的抑制和刺激作用。II. 分别存在刺激细胞和抑制细胞的证据。
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Subpopulations of T-lymphocytes. Physical separation, functional specialisation and differentiation pathways of sub-sets of thymocytes and thymus-dependent peripheral lymphocytes.T淋巴细胞亚群。胸腺细胞和胸腺依赖性外周淋巴细胞亚群的物理分离、功能特化及分化途径。
Transplant Rev. 1975;25:163-210.
5
Ly antigens: markers of T cell function on mouse spleen cells.Ly抗原：小鼠脾细胞上T细胞功能的标志物。
J Immunol. 1975 Dec;115(6):1555-7.
6
Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.带有不同Ly抗原的T淋巴细胞功能亚类。I. 功能不同的T细胞亚类的产生是一个独立于抗原的分化过程。
J Exp Med. 1975 Jun 1;141(6):1376-89. doi: 10.1084/jem.141.6.1376.
7
An improved technique for obtaining E rosettes with human lymphocytes and its use for B cell purification.一种用于获取人淋巴细胞E玫瑰花结的改良技术及其在B细胞纯化中的应用。
J Immunol Methods. 1976;13(2):175-82. doi: 10.1016/0022-1759(76)90156-3.
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Expression of a receptor for IgM by human T cells in vitro.人T细胞在体外表达IgM受体。
Eur J Immunol. 1975 Aug;5(8):565-9. doi: 10.1002/eji.1830050812.
9
Receptors for IgG molecules on human lymphocytes forming spontaneous rosettes with sheep red cells.人淋巴细胞上与绵羊红细胞形成自发玫瑰花结的IgG分子受体。
Eur J Immunol. 1975 Jan;5(1):70-2. doi: 10.1002/eji.1830050115.
10
Subpopulations of human T cells identified by receptors for immunoglobulins and mitogen responsiveness.通过免疫球蛋白受体和丝裂原反应性鉴定的人类T细胞亚群。
J Immunol. 1976 Dec;117(6):2171-4.

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