与使用伯氨喹作为组织裂殖体杀灭剂和配子体杀灭剂相关的临床问题。
Clinical problems associated with the use of primaquine as a tissue schizontocidal and gametocytocidal drug.
作者信息
Clyde D F
出版信息
Bull World Health Organ. 1981;59(3):391-5.
Abstract
Clinically important side-effects of primaquine are reviewed. These include gastrointestinal disturbances, methaemoglobinaemia, acute intravascular haemolysis in individuals deficient in glucose-6-phosphate dehydrogenase (G6PD), and possibly immunosuppression through inhibition of lymphocyte proliferation. Dosages of 30 or 45 mg (base) of primaquine, given at weekly intervals, are suitable for patients with G6PD deficiency. If possible, primaquine should not be administered until the acute symptoms of the malaria attack have been brought under control.
摘要
本文综述了伯氨喹的临床重要副作用。这些副作用包括胃肠道不适、高铁血红蛋白血症、葡萄糖-6-磷酸脱氢酶（G6PD）缺乏个体的急性血管内溶血，以及可能通过抑制淋巴细胞增殖导致的免疫抑制。对于G6PD缺乏的患者，每周间隔给予30或45毫克（碱基）伯氨喹的剂量是合适的。如果可能，在疟疾发作的急性症状得到控制之前不应使用伯氨喹。
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Radical cure of Chesson strain vivax malaria in man by 7, not 14, days of treatment with primaquine.通过使用伯氨喹进行7天而非14天的治疗，可实现对人类切森株间日疟的根治。
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