Elston C W, Cotton R E, Davies C J, Blamey R W
Histopathology. 1978 Jul;2(4):239-54. doi: 10.1111/j.1365-2559.1978.tb01717.x.
Two methods of obtaining a pre-operative diagnosis of carcinoma of the breast are compared. Tru-Cut needle biopsy was carried out on 368 consecutive patients with palpable breast lumps, and both Tru-Cut biopsy and fine needle aspiration cytology were performed during part of this study on 163 of the patients. A final histological diagnosis was obtained in each patient, at excision biopsy or mastectomy. There were 278 patients with carcinoma and 90 with benign breast disease. A correct positive diagnosis of carcinoma was made by the Tru-Cut method in 73.5% of cases, but in only 52% of cases by aspiration cytology. More importantly, there were no false positive diagnoses of carcinoma with Tru-Cut biopsy, but five cases of benign breast disease were incorrectly diagnosed as carcinoma by aspiration cytology. It is concluded that Tru-Cut biopsy is sufficiently reliable to be able to proceed direct to mastectomy following a positive diagnosis of carcinoma, in distinction to aspiration cytology with which an unacceptably high number of false positives occurs. The benefits of a pre-operative Tru-Cut biopsy diagnosis are identified.
对两种获取乳腺癌术前诊断的方法进行了比较。对368例可触及乳腺肿块的连续患者进行了Tru-Cut针吸活检，在本研究的部分时间里，对其中163例患者同时进行了Tru-Cut活检和细针穿刺细胞学检查。通过切除活检或乳房切除术，每位患者都获得了最终的组织学诊断。有278例患者患有癌症，90例患有良性乳腺疾病。Tru-Cut方法对癌症的正确阳性诊断率为73.5%，而细针穿刺细胞学检查仅为52%。更重要的是，Tru-Cut活检没有对癌症的假阳性诊断，但有5例良性乳腺疾病被细针穿刺细胞学检查错误诊断为癌症。结论是，Tru-Cut活检足够可靠，在癌症阳性诊断后能够直接进行乳房切除术，这与细针穿刺细胞学检查不同，后者出现了数量高得不可接受的假阳性。确定了术前Tru-Cut活检诊断的益处。
