神经刺激以及去甲肾上腺素或氯化钾给药对兔肠系膜动脉床灌注液中前列腺素I2、E2和F2α释放的影响。
Effects of nerve stimulation and of administration of noradrenaline or potassium chloride upon the release of prostaglandins, I2, E2, and F2 alpha from te perfused mesenteric arterial bed of the rabbit.
作者信息
Pipili E, Poyser N L
出版信息
Br J Pharmacol. 1981 Jan;72(1):89-93. doi: 10.1111/j.1476-5381.1981.tb09109.x.
Abstract
1 The release of prostaglandin I2 (PGI2), PGE2 and PGF2 alpha from the perfused mesenteric arterial bed of the rabbit was examined at rest, following nerve stimulation and following noradrenaline (NA) or potassium chloride (KCl) administration. 2 Stimulation of adrenergic nerves at 10 Hz caused a significant increase in the release of both PGI2, (assayed in terms of 6-oxo-PGF1 alpha) and PGE2 but a significant decrease in the release of PGF2 alpha. 3 Exogenous Na (2 micrograms) increased the output of PGI2 and PGE2 but left the output of PGF2 alpha unaffected. 4 KCl (15 mg) significantly increased the output of PGF2 alpha but left the output of PGF2 unaffected. 5 It is concluded that PGI2 and PGE2 output from the mesenteric arterial bed of the rabbit increases following stimulation of adrenoceptors. The sympathetic nervous system may therefore modulate PGI2/platelet interaction. 6 Prostaglandins released from the blood vessels by sympathetic nerve stimulation may also modulate adrenergic transmission to the blood vessels.
摘要
- 研究了兔肠系膜动脉床在静息状态、神经刺激后以及给予去甲肾上腺素（NA）或氯化钾（KCl）后前列腺素I2（PGI2）、前列腺素E2（PGE2）和前列腺素F2α（PGF2α）的释放情况。2. 以10赫兹频率刺激肾上腺素能神经，导致PGI2（以6-氧代-PGF1α测定）和PGE2的释放显著增加，但PGF2α的释放显著减少。3. 外源性NA（2微克）增加了PGI2和PGE2的释放量，但对PGF2α的释放量没有影响。4. KCl（15毫克）显著增加了PGF2α的释放量，但对PGI2的释放量没有影响。5. 得出结论，刺激肾上腺素能受体后，兔肠系膜动脉床的PGI2和PGE2释放量增加。因此，交感神经系统可能调节PGI2/血小板相互作用。6. 交感神经刺激从血管释放的前列腺素也可能调节肾上腺素能向血管的传递。
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