合成血小板激活因子对人中性粒细胞功能的影响。
Effect of synthetic PAF-acether on human neutrophil function.
作者信息
Czarnetzki B M, Benveniste J
出版信息
Agents Actions. 1981 Dec;11(6-7):549-50. doi: 10.1007/BF01978734.
PMID:7041568
Abstract
Synthetic PAF-acether was studied for its effect on human neutrophil migration and secretion. Based on checkerboard analysis, the factor is chemokinetic for neutrophils, but it also enhances ECF-stimulated chemotaxis. By itself, PAF-acether does not induce ECF or beta-glucuronidase secretion from neutrophils, but it causes a dose-dependent enhancement of release in the presence of zymosan. PAF-acether thus potentially modulates neutrophil functions during inflammatory events.
摘要
研究了合成血小板活化因子（PAF-乙醚）对人中性粒细胞迁移和分泌的影响。基于棋盘分析，该因子对中性粒细胞具有化学促动作用，但它也增强了表皮细胞生长因子（ECF）刺激的趋化性。PAF-乙醚本身不会诱导中性粒细胞分泌ECF或β-葡萄糖醛酸酶，但在存在酵母聚糖的情况下，它会导致释放呈剂量依赖性增强。因此，PAF-乙醚可能在炎症事件中调节中性粒细胞功能。
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