伴放线放线杆菌释放有毒微囊泡。
Release of toxic microvesicles by Actinobacillus actinomycetemcomitans.
作者信息
Nowotny A, Behling U H, Hammond B, Lai C H, Listgarten M, Pham P H, Sanavi F
出版信息
Infect Immun. 1982 Jul;37(1):151-4. doi: 10.1128/iai.37.1.151-154.1982.
Abstract
Oral isolates of Actinobacillus actinomycetemcomitans (strain Y4) release spherical microvesicles in large numbers during normal growth. The biological activities of these products were studied, and it was estimated that approximately 1/10 of their dry weight was made up of heat- and proteolysis-resistant endotoxin. The chicken embryo lethality and bone-resorbing activity of the microvesicles were heat stable but proteolysis sensitive. Other laboratories have reported the presence of a heat- and proteolysis-sensitive leukotoxin in similar preparations. Accordingly, the microvesicles released by strain Y4 may contain, in addition to endotoxin, several potent substances which are highly toxic and active in bone resorption, and these may be significant factors in the pathogenesis of periodontal diseases.
摘要
伴放线放线杆菌（菌株Y4）的口腔分离株在正常生长过程中大量释放球形微泡。对这些产物的生物活性进行了研究，估计其干重的约1/10由耐热和抗蛋白水解的内毒素组成。微泡的鸡胚致死活性和骨吸收活性对热稳定，但对蛋白水解敏感。其他实验室报道在类似制剂中存在一种对热和蛋白水解敏感的白细胞毒素。因此，Y4菌株释放的微泡除内毒素外，可能还含有几种剧毒且具有骨吸收活性的物质，这些可能是牙周疾病发病机制中的重要因素。
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