Ishikawa K, Shirato C, Yotsukura M, Ishihara T, Tamura T, Inoue M
J Electrocardiol. 1982 Jan;15(1):23-30. doi: 10.1016/s0022-0736(82)80041-1.
In a 3-year follow-up study, sequential changes in the number of high frequency notches (HFN) on QRS complexes were investigated on 72 cases with progressive muscular dystrophy of the Duchenne type (PMD). The patients were classified into eight stages from the mildest, S(1), to the most severe, S(8), according to Swinyard-Deaver's criteria. The number of HFN progressively increased with advancing Swinyard-Deaver's stage. In the terminal stage, however, the number of HFN tended to decrease. The present observations show that the patient tends to have a small number of HFN in the early stages of the disease; with increasing severity of the disease he develops a larger number; in the terminal stage he again exhibits relatively few notches. It is concluded therefore that significant increases or decreases in the count of HFN on QRS complexes can be useful indicators for estimating the extent and severity of cardiac involvement in PMD.
在一项为期3年的随访研究中，对72例杜兴型进行性肌营养不良症（PMD）患者的QRS波群高频切迹（HFN）数量的连续变化进行了调查。根据斯温亚德 - 迪弗标准，患者被分为从最轻的S(1)到最严重的S(8)八个阶段。HFN的数量随着斯温亚德 - 迪弗阶段的推进而逐渐增加。然而，在终末期，HFN的数量趋于减少。目前的观察结果表明，患者在疾病早期往往有少量的HFN；随着疾病严重程度的增加，HFN数量增多；在终末期，HFN数量又相对较少。因此得出结论，QRS波群上HFN计数的显著增加或减少可作为评估PMD心脏受累程度和严重性的有用指标。
