在食蟹猴中用 dexamethasone 预防输精管切除术后精子凝集和制动抗体的形成。

Sperm-agglutinating and -immobilizing antibody formation following vasectomy prevented with dexamethasone in cynomolgus monkeys.

作者信息

Curtis G L, Ryan W L, Lacy S S

出版信息

Fertil Steril. 1982 Jul;38(1):97-9. doi: 10.1016/s0015-0282(16)46402-2.

Abstract

Cynomolgus monkeys (Macaca fascicularis) were treated with 1.5 mg/kg dexamethasone (DEX) before (4 to 2 days) and after (0, 2, 4, and 7 days) vasectomy. Of the four monkeys treated with DEX, only one developed sperm antibody as measured by sperm-agglutinating and sperm-immobilizing assays. All six of the vasectomized monkeys not given DEX developed both agglutinating and immobilizing sperm antibodies. In this study, DEX given before and after vasectomy blocked sperm-agglutinating and -immobilizing antibody formation. We conclude that the major antigenic exposure to sperm responsible for sperm-agglutinating and -immobilizing antibody comes at the time of vasectomy.

摘要

食蟹猴（猕猴）在输精管结扎术前（4至2天）和术后（0、2、4和7天）接受1.5mg/kg地塞米松（DEX）治疗。在接受DEX治疗的四只猴子中，通过精子凝集和精子制动试验检测，只有一只产生了精子抗体。未给予DEX的所有六只输精管结扎猴子都产生了凝集和制动精子抗体。在本研究中，输精管结扎术前和术后给予DEX可阻止精子凝集和制动抗体的形成。我们得出结论，导致精子凝集和制动抗体的精子主要抗原暴露发生在输精管结扎时。