一种采用高压液相色谱法测定血清中氢氯噻嗪的灵敏方法。
A sensitive method for the determination of hydrochlorothiazide in serum by high pressure liquid chromatography.
作者信息
Robinson W T, Cosyns L
出版信息
Clin Biochem. 1978 Aug;11(4):172-4. doi: 10.1016/s0009-9120(78)90434-4.
PMID:709810
Abstract
A high pressure liquid chromatographic method for the determination of hydrochlorothiazide in serum has been elaborated and verified in a blood level study in normal individuals given a single oral dose of 50 mg hydrochlorothiazide. Based on 5 ml of serum, the limit of detection of the method is 2 ng/ml.
摘要
已建立了一种用于测定血清中氢氯噻嗪的高压液相色谱法，并在给予单次口服50毫克氢氯噻嗪的正常个体的血药浓度研究中进行了验证。基于5毫升血清，该方法的检测限为2纳克/毫升。
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