睾酮长期治疗对大鼠睾丸间质细胞形态的影响：一项超微结构立体学研究

Effects of a chronic treatment with testosterone on the morphology of the interstitial cells of the rat testis: an ultrastructural stereologic study.

作者信息

Mazzocchi G, Robba C, Rebuffat P, Gottardo G, Nussdorfer G G

出版信息

Int J Androl. 1982 Apr;5(2):130-6. doi: 10.1111/j.1365-2605.1982.tb00240.x.

DOI:10.1111/j.1365-2605.1982.tb00240.x

Abstract

The suppressive effects of chronic testosterone administration on the rat testicular interstitial cells (Leydig cells) were investigated by stereological methods. The volume of cells, nuclei, mitochondrial compartment and smooth endoplasmic reticulum (SER), as well as the surface area of SER and mitochondrial cristae decreased significantly as a function of the duration of treatment. The decrease in the SER volume accounted for about 75-80% of that in the cell volume. These findings lend support to the view that SER is the subcellular organelle more responsive to the changes in the functional activity of rat Leydig cells.

摘要

采用体视学方法研究了长期给予睾酮对大鼠睾丸间质细胞（Leydig细胞）的抑制作用。随着治疗时间的延长，细胞、细胞核、线粒体区室和平滑内质网（SER）的体积，以及SER和线粒体嵴的表面积均显著减小。SER体积的减小约占细胞体积减小的75 - 80%。这些发现支持了这样一种观点，即SER是对大鼠Leydig细胞功能活性变化更敏感的亚细胞器。