[Lichen myxedematosus and scleromyxedema].

Review of the clinical picture, dynamics of the disease, associated symptoms and signs, etiopathology as well as treatment and prognosis of lichen myxedematosus and scleromyxedema. Diagnostic criteria are wax-like papules and leather-like skin thickening, an increase in concentration of acid mucopolysaccharides consisting mainly of hyaluronic acid in the dermis, lympho-plasmacytoid infiltrates in the skin and the bone marrow, normal thyroid function, and paraproteinemia of light chain type lambda or kappa. The nosologic connection of both manifestations implying a single disease entity is emphasized by two of our clinical observations of the transition of lichen myxedematosus to scleromyxedema. An attempt will be made to interpret this as a certain kind of myelomesenchymal syndrome.