Voors A W, Webber L S, Berenson G S
Am J Epidemiol. 1982 Aug;116(2):276-86. doi: 10.1093/oxfordjournals.aje.a113412.
Resting heart rates were ascertained during the 1978-1979 school year in 3590 children aged 5-17 years in the biracial geographic population of Bogalusa, Louisiana. These rates were found to be relatively independent of the method of measurement, whether supine by physician's stethoscope or dressed sitting radial pulse taken by a nurse, and in either case adhering to a strict measurement protocol. Apart from the known influences of age and sex, the authors found a small but consistent racial influence, with whites having 3-4 beats/min higher rates than blacks. Controlling for age, the authors found heart rate to be positively correlated with blood pressure in whites and with subcapsular skinfold thickness in boys. No consistent relation between heart rate and amount of cigarettes smoked was observed. Boys in the upper five percentiles of blood pressure-heart rate ("double") product values were found to have about twice the subscapular skinfold thickness compared to the lower five percentiles. Likewise, boys in the upper five percentiles of subscapular skinfold thickness had significantly increased double products. Since the double product is an index of cardiac oxygen consumption, this finding could point to a possible etiologic link between obesity and chronic cardiac stress in males beyond the mediation of lipoproteins, cholesterol, and diabetes mellitus in contributing to atherosclerotic heart disease, but this issue needs further study. Ascertainment of resting heart rate provides an additional parameter in the study of cardiovascular risk factor variables, in youth as in adulthood, to supplement the natural history of the atherosclerosis-hypertension syndrome with its sequelae.
1978 - 1979学年期间,在路易斯安那州博加卢萨的双种族地理区域,对3590名5至17岁儿童的静息心率进行了测定。结果发现,静息心率相对独立于测量方法,无论是由医生用听诊器在仰卧位测量,还是由护士在穿着衣服坐着时测量桡动脉脉搏,且两种情况下均严格遵循测量方案。除了已知的年龄和性别影响外,作者还发现了一种虽小但一致的种族影响,白人的心率比黑人高3 - 4次/分钟。在控制年龄后,作者发现白人的心率与血压呈正相关,男孩的心率与肩胛下皮褶厚度呈正相关。未观察到心率与吸烟量之间存在一致关系。血压 - 心率(“双乘积”)值处于前百分之五的男孩,其肩胛下皮褶厚度约为后百分之五男孩的两倍。同样,肩胛下皮褶厚度处于前百分之五的男孩,其双乘积显著增加。由于双乘积是心脏氧消耗的指标,这一发现可能表明在男性中,肥胖与慢性心脏应激之间可能存在病因学联系,这种联系超出了脂蛋白、胆固醇和糖尿病在促成动脉粥样硬化性心脏病过程中的中介作用,但这一问题需要进一步研究。静息心率的测定为心血管危险因素变量的研究提供了一个额外参数,无论在青年还是成年时期,都可补充动脉粥样硬化 - 高血压综合征及其后遗症的自然史。