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兔血浆脂蛋白间视黄酯和胆固醇酯的交换

Exchange of retinyl and cholesteryl esters between lipoproteins of rabbit plasma.

作者信息

Zilversmit D B, Morton R E, Hughes L B, Thompson K H

出版信息

Biochim Biophys Acta. 1982 Jul 20;712(1):88-93. doi: 10.1016/0005-2760(82)90088-1.

Abstract

Normal or hypercholesterolemic rabbit plasma stimulates the transfer of retinyl ester as well as cholesteryl ester from rabbit lymph chylomicrons, chylomicron remnants or from cholesteryl ester-rich plasma VLDL to the d greater than 1.019 lipoprotein fractions. The presence of p-chloromercuriphenylsulfonate does not inhibit the transfer of these esters. Partially purified lipid transfer protein from rabbit or from human plasma also accelerates the transfer of the above esters. Whereas the rabbit plasma transfer protein preferentially accelerates the transfer of retinyl ester, the human plasma transfer protein appears to have a somewhat greater stimulating effect on the transfer of cholesteryl ester from low- to high-density lipoproteins.

摘要

正常或高胆固醇血症兔血浆可刺激视黄酯以及胆固醇酯从兔淋巴乳糜微粒、乳糜微粒残粒或富含胆固醇酯的血浆极低密度脂蛋白转移至密度大于1.019的脂蛋白组分中。对氯汞苯磺酸盐的存在并不抑制这些酯的转移。来自兔或人血浆的部分纯化脂质转运蛋白也可加速上述酯的转移。兔血浆转运蛋白优先加速视黄酯的转移,而人血浆转运蛋白似乎对胆固醇酯从低密度脂蛋白向高密度脂蛋白的转移具有更大的刺激作用。

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