Band P R, Besner J G, Leclaire R, Girard C, Diorio G, Deschamps M, Gélinas M, Larochelle D
Cancer Treat Rep. 1982 Sep;66(9):1759-61.
A phase I study of 13-cis-retinoic acid was done in 16 patients with head and neck malignancies using a modified Fibonacci search scheme, with individual doses ranging from 20 to 120 mg/m2. Drug doses greater than 60 mg/m2 induced intense headaches, urethritis, desquamative dermatitis, vertigo, and ataxia. The severity of these side effects precludes the use of 13-cis-retinoic acid as a potential chemopreventive agent at doses greater than 60 mg/m2.
对16例头颈部恶性肿瘤患者进行了一项13 - 顺式维甲酸的I期研究，采用改良的斐波那契搜索方案，个体剂量范围为20至120mg/m²。大于60mg/m²的药物剂量会引发剧烈头痛、尿道炎、剥脱性皮炎、眩晕和共济失调。这些副作用的严重程度使得在剂量大于60mg/m²时，不能将13 - 顺式维甲酸用作潜在的化学预防剂。
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