[肿瘤组织培养液对血小板聚集的体外作用。II. 实验性肿瘤]

[In vitro effect of culture fluids from neoplastic tissues on platelet aggregation. II. Experimental tumors].

作者信息

Pacchiarini L, Serra L, Grignani G, Gamba G, Gorini M

出版信息

Boll Soc Ital Biol Sper. 1982 Jul 15;58(13):854-9.

Abstract

We have investigated the effects on platelet function of culture media from 2 sublines of a benzopyrene-induced murine sarcoma (mFS6). Platelet aggregation was investigated according to Born's method. The cell line with greater "in vivo" invasiveness showed higher aggregating activity and higher increase on ADP-induced aggregation; these effects were inhibited by the preincubation of platelets with Aspirin (0,1 mM). These results suggest the role of platelets in metastasis formation; the possibility to inhibit pharmacologically the interactions between platelets and tumour cells could have important implications from both speculative and practical viewpoints.

摘要

我们研究了苯并芘诱导的小鼠肉瘤（mFS6）两个亚系的培养基对血小板功能的影响。根据博恩氏方法研究血小板聚集情况。具有更强“体内”侵袭性的细胞系表现出更高的聚集活性以及对ADP诱导的聚集有更高的增加；这些效应可被血小板与阿司匹林（0.1 mM）预孵育所抑制。这些结果提示血小板在转移形成中的作用；从理论和实际观点来看，通过药理学方法抑制血小板与肿瘤细胞之间的相互作用可能具有重要意义。