冷适应小鼠对胰高血糖素的产热反应。

Thermogenic response to glucagon in cold-acclimated mice.

作者信息

Doi K, Kuroshima A

出版信息

Jpn J Physiol. 1982;32(3):377-85. doi: 10.2170/jjphysiol.32.377.

DOI:10.2170/jjphysiol.32.377

PMID:7131937

Abstract

Heat production after injection of glucagon and norepinephrine was measured in warm- and cold-acclimated mice. Glucagon and norepinephrine in a dose of 100 microgram/100 g caused a marked increase in oxygen consumption. Heat production after administration of glucagon and norepinephrine was significantly potentiated by cold acclimation. A significant positive correlation was observed between the increase in oxygen consumption after injection of glucagon or norepinephrine and the weight of brown adipose tissue in warm- and cold-acclimated mice. These findings indicate that glucagon is a calorigenic hormone in mice and its effect is potentiated by cold acclimation possibly due to an activation of thermogenic mechanism(s) in brown adipose tissue.

摘要

在经过温暖环境适应和寒冷环境适应的小鼠中，测量了注射胰高血糖素和去甲肾上腺素后的产热情况。剂量为100微克/100克的胰高血糖素和去甲肾上腺素会导致耗氧量显著增加。寒冷环境适应显著增强了注射胰高血糖素和去甲肾上腺素后的产热。在经过温暖环境适应和寒冷环境适应的小鼠中，注射胰高血糖素或去甲肾上腺素后耗氧量的增加与棕色脂肪组织的重量之间存在显著正相关。这些发现表明，胰高血糖素在小鼠中是一种产热激素，寒冷环境适应可能通过激活棕色脂肪组织中的产热机制来增强其作用。