正常人L(+)-乳酸代谢模型。

A model of L(+)-lactate metabolism in normal man.

作者信息

Connor H, Woods H F, Ledingham J G, Murray J D

出版信息

Ann Nutr Metab. 1982;26(4):254-63. doi: 10.1159/000176571.

Abstract

Mathematical models were used to study the elimination of L(+)-lactate during and after an intravenous load of unlabelled sodium L(+)-lactate in 20 normal postprandial subjects. Clearance of L(+)-lactate from blood was 17.9 +/- 1.1 ml (kg BW)-1 min-1 and the endogenous production rate of L(+)-lactate at rest was 1.38 +/- 0.16 mol (70 kg BW)-1 24 h-1. Clearance and production were unchanged after a 36-hour fast in 4 subjects. Renal excretion of L(+)-lactate accounted for less than 1.2% of the infused load. Clearance of L(+)-lactate was closely related to the pre-infusion concentrations of ketone bodies and alanine.

摘要

运用数学模型研究了20名正常餐后受试者静脉注射未标记的L(+)-乳酸钠期间及之后L(+)-乳酸的清除情况。血液中L(+)-乳酸的清除率为17.9±1.1 ml/(kg体重)·min-1，静息状态下L(+)-乳酸的内源性生成率为1.38±0.16 mol/(70 kg体重)·24 h-1。4名受试者禁食36小时后，清除率和生成率未发生变化。L(+)-乳酸的肾排泄量占输注量的比例不到1.2%。L(+)-乳酸的清除率与输注前酮体和丙氨酸的浓度密切相关。