[Effect of acetyllactoylcholine-1,5-naphthalene disulfonate on the motility of stomach].

The effect of TM-723 on the motility of stomach was investigated by using the electromyogram, extraluminal strain gauge force transducer in dog and by measuring the human gastric emptying time. Three mongrel dogs were equipped with two bipolar electrodes on the serosal surface of the antrum and single bipolar electrode and single strain gauge on the surface of the body. Both the peristaltic spike discharge and contractile activity were recorded during 30 minutes before and 60 minutes after administration of TM-723 1 mg/kg, 3 mg/kg and 5 mg/kg, iv. The peristaltic spikes were suddenly disappeared on administration of TM-723 and after then, recurrent peristaltic spikes were recognized with prolonged interval and increased propagation velocity for about four minutes. The contractile activity increased with the administration of TM-723 for a minute. Gastric emptying time were measured on four healthy men by using of the test meal containing 300 muCi of 99mTc-DTPA before and after administration of TM-723 50 mg per os. The following results were obtained that three of four men had accelerated emptying time and one had no remarkable changes after taking TM-723. These studies suggest that TM-723 activates the motility of the stomach.